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Subcutaneous injection delivers the peptide to the dermal and subdermal layers where follicles reside

skin is one of the most readily accessible organs of the human body, it is very difficult barrier to the ingress of materials allowing only small quantities of a drug to penetrate over a period of time

The extracellular matrix components affect growth, differentiation and mobility of stem cells through a multitude of peptide regulators, adhesions molecules, growth factors and transcriptional factors [ 14 ]

IL-4 and IL-13 suppress the production of filaggrin, a structural protein critical for maintaining the stratum corneum